Br J Dermatol. 1994;130(4):405
Immunohistological study of the development of the cellular infiltrate in the pelage follicles of the DEBR model for alopecia areata.Zhang JG,
edited for use in this hair loss treatment blog
The Dundee experimental bald rat undergoes hair loss associated with perifollicular infiltrates of mononuclear cells (MNC), a pathological characteristic of human alopecia areata (AA). ..snip… There was a good correlation between the degree of leucocyte (OX-1+) infiltration of anagen hair follicles and the development of hair loss. ..snip… Active and established lesional rats, i.e. animals with overt loss of hair, showed a significant increase in the degree of MNC infiltration and the proportion of infiltrated follicles, the majority of which were in dystrophic anagen. ..snip.. These results show marked similarities to lesional human AA. They also focus on a possible active role for CD8+ cells in the pathogenesis of hair loss in the DEBR rat.